Description

Advanced Mitochondrial Research: SS-31

SS-31 (also known as Elamipretide or MTP-131) is a synthetic mitochondria-targeted tetrapeptide engineered to optimize cellular bioenergetics. Built upon an alternating aromatic-cationic structural motif (D-Arg-Dmt-Lys-Phe-NH₂), it selectively crosses cell membranes to target the inner mitochondrial membrane without relying on specific receptor pathways. Sourcing high-purity research materials is crucial for analytical laboratories investigating oxidative stress, cellular aging, and bioenergetic dysfunction.

Technical & Product Specifications

• Sample Size: 50ml / Lyophilized Powder

• Purity: >99% Purity

• Molecular Weight: 639.8 g/mol

• Storage: Store at -20°C (Desiccated)

• CAS No.: 736992-21-5

Targeted Mechanism of Action

Unlike conventional anti-oxidant compounds that act broadly in the cytosol, the ss-31 peptide partitions directly into the inner mitochondrial membrane. Its core physiological mechanisms include:

• Cardiolipin Binding: Selectively interacts with cardiolipin, an essential inner-membrane phospholipid, preserving membrane curvature and cristae structural integrity.

• Electron Transport Efficiency: Optimizes respiratory chain complex alignment, promoting efficient ATP synthesis while minimizing electron leak.

• ROS Reduction: Reduces the intracellular production of damaging reactive oxygen species (ROS) directly at the primary source of metabolic oxidative stress.

This targeted bioenergetic enhancement makes the ss-31 peptide buy option a high-value reference standard for researchers studying metabolic resilience, cardiac hypertrophy, and neurodegenerative pathways.

Experimental Considerations & Dosage Handling

In pre-clinical trial design and cell culture assays, determining an accurate ss-31 peptide dosage is vital for maintaining reproducible quantitative results. Laboratory assays frequently evaluate parameter ranges across variable concentrations to observe dose-dependent shifts in mitochondrial membrane potential.

Comparative experimental setups—such as evaluating ss-31 (30mg) – liberty peptides standards alongside custom in-house control samples—help ensure that variations in source manufacturing do not alter baseline measurements. Establishing strict reconstitution protocols with sterile bacteriostatic water guarantees long-term peptide stability and prevents premature degradation in laboratory settings.

Premium Research Reagents

For academic research institutes, biotechnology facilities, and analytical laboratories, Receptor Chemicals delivers analytical-grade compounds subjected to rigorous testing. Our inventory maintains batch-to-batch consistency to support your most demanding experimental protocols.