Description

Extended Half-Life GHRH Analog: CJC-1295 with DAC

CJC-1295 with DAC is a synthetic 30-amino acid peptide analog of Growth Hormone-Releasing Hormone (GHRH). Engineered with a Drug Affinity Complex (DAC) modification, it covalently binds to circulating serum albumin upon administration. This bioconjugation significantly enhances structural stability, preventing rapid enzymatic degradation and systemic clearance. Sourcing analytical-grade research materials is essential for laboratories investigating long-acting pituitary receptor dynamics and endocrine pathways.

Technical & Product Specifications

• Sample Size: 2mg / 5mg Lyophilized Vial

• Purity: >99% Purity (HPLC Verified)

• CAS No.: 446262-90-4

• Molecular Weight: ~3,647.25 g/mol

• Solubility: Soluble in Sterile Water / Bacteriostatic Water

• Storage: Store at -20°C (Lyophilized)

Extended Pharmacokinetics and Receptor Dynamics

The primary innovation of cjc-1295 with dac lies in its modified structure, which preserves biological activity over an extended duration:

• Serum Albumin Binding: The maleimide moiety chemically links to endogenous albumin, protecting the peptide from cleavage by dipeptidyl peptidase-IV (DPP-IV).

• Extended Activity: While unmodified GHRH analogs exhibit rapid clearance within minutes, the cjc-1295 with dac half-life extends up to 6 to 8 days in experimental models.

• Sustained Somatotroph Stimulation: Delivers continuous, pulsatile stimulation to pituitary receptors rather than short-lived concentration spikes.

Endocrine Research and Benefits

Investigating sustained GHRH agonism provides researchers with valuable data regarding pituitary hormone regulation. Key observed cjc-1295 with dac benefits in preclinical trials include continuous elevation of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) plasma levels. These downstream pathways are routinely evaluated for their impact on nitrogen retention, protein synthesis, cellular repair, and lipid oxidation models.

In experimental protocols, researchers configure specific cjc-1295 with dac dosage parameters to observe serum concentration steady-states across multi-week observation periods without necessitating daily dosing. High-purity reference materials ensure baseline consistency and reproducible outcomes across all analytical assays.

Sourcing High-Purity Research Peptides

For academic institutions, biotechnology facilities, and analytical laboratories requiring dependable research compounds, Receptor Chemicals provides high-grade peptides engineered for strict experimental standards. Our rigorous quality control processes guarantee structural integrity and batch-to-batch reliability for your scientific investigations.