Description

Next-Generation Peptides: PT-141

PT-141 (chemically known as Bremelanotide) represents a significant breakthrough in the study of central nervous system (CNS) receptor pathways and reproductive health sciences. Unlike traditional small-molecule therapies that target vascular mechanisms, this synthetic cyclic peptide acts centrally as a selective agonist at melanocortin receptors primarily MC3R and MC4R within the hypothalamus. Sourcing analytical-grade reference materials is vital for research facilities evaluating receptor dynamics, neuroendocrine signaling, and behavioral pharmacology.

Technical & Product Specifications

• Sample Size: 10mg

• Purity: >99% Purity

• Molecular Weight: ~1,025.2 g/mol

• Storage: Store at -20℃ (lyophilized solid)

• CAS No.: 189691-06-3

Central Nervous System Action & Research Dynamics

The primary distinction of the pt-141 peptide lies in its unique mechanism of action. Rather than dilating peripheral blood vessels directly, it crosses key central pathways to trigger dopamine release and neuronal activation in the medial preoptic area (mPOA) of the brain.

Researchers utilize this compound to explore several key physiological domains:

• Hypoactive Sexual Desire Study: Serves as a primary reference standard for examining neurobiological responses in models of hypoactive sexual desire disorder (HSDD).

• Melanocortin Signaling: Allows investigation into the dual roles of MC3R and MC4R activation in regulating autonomic balance, motivation, and metabolic homeostasis.

• Male & Female Behavioral Pathways: Evaluated extensively to observe gender-specific neurological responses, helping researchers evaluate efficacy metrics for pt-141 for men alongside female models in controlled preclinical trials.

Delivery Formulations & Experimental Standards

In laboratory settings, research design dictates the delivery vehicle used to assess bioactivity and receptor affinity:

• Intranasal Formulations: Investigators studying rapid mucosal absorption and direct central pathway transport frequently utilize pt-141 nasal spray configurations in experimental models.

• Subcutaneous Reconstitution: Lyophilized vials allow precise fluid reconstitution, enabling researchers to maintain strict control over test concentrations when calculating experimental pt-141 dosage parameters for cellular assays or animal models.

Sourcing High-Purity Research Reagents

For academic laboratories, contract research organizations (CROs), and analytical facilities, obtaining consistently pure reagents is essential for producing valid, reproducible data. Receptor Chemicals provides top-tier research compounds subjected to rigorous HPLC and mass spectrometry verification. Our commitment to chemical integrity ensures that your facility receives stable, reliable materials tailored for advanced scientific discovery.