Description

Advanced Melanocortin Research: MT1

MT1 (Melanotan-1 / Afamelanotide) is a synthetic tridecapeptide analog of the naturally occurring $\alpha$-melanocyte-stimulating hormone ($\alpha$-MSH). Engineered to provide increased potency and a longer biological half-life than its native counterpart, it selectively targets the Melanocortin 1 Receptor (MC1R). In laboratory and cellular models, activation of MC1R stimulates melanogenesis—the physiological pathway responsible for synthesizing eumelanin photoprotective pigments.

Technical & Product Specifications

• Size: 10mg

• Purity: >99% Purity (HPLC Verified)

• Molecular Weight: ~1,646.85 g/mol

• Storage: Store lyophilized powder at -20℃ (up to 3 years)

• CAS No.: 75921-69-6

Selective MC1R Agonism & Cellular Mechanisms

Unlike broader, non-selective melanocortin analogs, the mt1 peptide demonstrates high specificity toward MC1R receptors located on melanocytes. This receptor selectivity makes it a critical tool for researchers investigating:

• Eumelanin Synthesis & Photoprotection: Evaluating cellular responses to oxidative stress and ultraviolet-induced DNA damage in epidermal tissues.

• Receptor Signaling Pathways: Mapping G-protein coupled receptor (GPCR) cascades and intracellular cyclic AMP (cAMP) accumulation.

• Comparative Kinetics: Analyzing binding affinities compared to second-generation peptides and endogenously secreted peptides.

Experimental Delivery Formats & Dosage Protocols

In preclinical literature, determining an accurate mt1 peptide dosage depends heavily on the model under investigation, target cell density, and assay duration. Researchers examine diverse administration methods to measure mucosal absorption versus traditional reconstitution:

• Lyophilized Vials: Standard high-purity powder optimized for reconstituted aqueous assays.

• Intranasal Formulations: Exploring non-invasive cellular delivery via mt1 peptide nasal spray vehicle systems to observe systemic peptide uptake kinetics.

Maintaining rigorous reconstitution protocols prevents peptide degradation and ensures consistent, reproducible results across cellular assays.

High-Purity Research Reagents

For research institutions, analytical laboratories, and academic facilities looking to mt1 peptide buy options, Receptor Chemicals provides analytical-grade compounds backed by strict quality verification. Our supply chain ensures batch-to-batch consistency and structural integrity for all experimental and analytical research applications.