Description

Telomere & Longevity Biology Reagents: Epitalon

Epitalon (also known as Epithalon or AEDG peptide) is a synthetic tetrapeptide comprised of four amino acids: L-alanyl-L-$\alpha$-glutamyl-L-$\alpha$-aspartylglycine. Originally modeled after epithalamin—a natural polypeptide extract derived from the pineal gland this compound is widely studied in gerontology, cell biology, and longevity research. Its primary mechanism of action in laboratory models revolves around its ability to upregulate telomerase activity, thereby maintaining telomere length and supporting cellular replication cycles.

Technical & Product Specifications

• Size: 10mg Lyophilized Powder

• Purity: ≥99% (HPLC Verified)

• Molecular Weight: 390.35 g/mol

• Solubility: Soluble in sterile water or buffer solution

• Storage: Store at -20°C (lyophilized)

• CAS No.: 307297-39-8

Mechanisms in Cellular Aging & Telomere Research

In vitro and animal model studies demonstrate that the epitalon peptide influences several foundational biomarkers associated with cellular senescence:

• Telomerase Activation: Stimulates the elongation of telomeres, overcoming the Hayflick limit of cellular division in cultured human fibroblasts.

• Neuroendocrine Modulation: Helps restore pineal gland function, regulating endogenous melatonin secretion and circadian rhythms in aging models.

• Antioxidant & DNA Repair: Reduces reactive oxygen species (ROS) levels while enhancing mitochondrial membrane potential and structural integrity.

Laboratory Handling & Dosage Considerations

When establishing testing parameters, researchers evaluate the epitalon dosage based on specific assay design, treatment duration, and cellular culture constraints. Standard protocols frequently investigate a generalized epitalon peptide dosage range across cyclic administration schedules to observe cumulative enzyme induction without downregulating receptor sensitivity. Utilizing an epitalon 10mg 99% pure lab tested peptide vial ensures that analytical experiments remain free from interfering byproduct contaminants, delivering clear, reproducible data across HPLC and mass spectrometry evaluations.

High-Purity Research Solvents & Compounds

For academic institutions, biotechnology firms, and medical research facilities requiring verified biochemicals, Receptor Chemicals delivers analytical-grade materials engineered to meet strict quality thresholds. Every lot undergoes rigorous testing to guarantee sequence accuracy, structural purity, and batch-to-batch consistency.