Description
Advanced Circadian & Metabolic Research: SR9011
Is a synthetic, small-molecule REV-ERB agonist designed to selectively bind to nuclear receptors REV alphaand REV-beta. By modulating these transcription factors, it plays a central role in regulating circadian rhythms, lipid homeostasis, and basal mitochondrial bioenergetics. This makes it an indispensable reference standard for laboratories studying metabolic pathways, energy expenditure, and cellular oxidation.
Technical & Product Specifications
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Sample Size: 30ml @ 10mg/ml (30 x 10mg)
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Purity: >98% Purity
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Molecular Weight (M.Wt): 479.04 g/mol
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Solubility: Soluble in Polyglycols
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Storage: Store at -20℃ (up to 3 years)
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CAS No.: 1379686-29-9
REV-ERB Agonism and Physiological Impacts
Evaluating the primary sr9011 benefits in preclinical models highlights how REV-ERB activation influences key cellular mechanisms:
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Mitochondrial Biogenesis & Respiration: Enhances mitochondrial density and oxygen consumption in skeletal muscle tissue, driving substrate oxidation.
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Lipid & Glucose Regulation: Suppresses hepatic lipogenesis and regulates plasma glucose levels by repressing specific target genes in liver and adipose tissues.
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Circadian Gene Expression: Alters the expression profiles of core clock genes, allowing researchers to explore metabolic alterations linked to circadian disruption.
Comparative Dynamics: SR9009 vs SR9011
When conducting comparative assays, researchers frequently contrast sr9009 vs sr9011. While both compounds act as potent REV-ERB agonists targeting identical biological receptors, SR9011 exhibits enhanced bioavailability and superior pharmacokinetic stability in in vitro and in vivo research protocols.
Additionally, despite frequent misclassification in vendor catalogs under the sr9011 sarm label, it is strictly a REV-ERB nuclear receptor agonist and does not interact with androgen receptors. For research institutions evaluating sr9011 for sale options, securing analytical-grade purity ensures reproducible experimental data free from interference.
High-Purity Reagents by Receptor Chemicals
Receptor Chemicals provides top-tier research solutions engineered for rigorous academic and laboratory testing. Our inventory undergoes thorough analytical validation to ensure structural accuracy, high purity, and batch consistency across all metabolic and circadian research applications.
