Description

Advanced Nootropic Research: Selank

Selank is a synthetic heptapeptide derived from the naturally occurring immunomodulatory tetrapeptide tuftsin. Engineered by adding a Proline-Glycine-Proline (PGP) tripeptide sequence to its C-terminus, this metabolic modification significantly increases enzymatic stability and extends its biological half-life in analytical models. Recognized for its dual nootropic and anxiolytic properties, it serves as an essential reference compound in neurochemical, cognitive, and immunological research.

Technical & Product Specifications

• Size: 10mg

• Purity: >99% Purity

• Molecular Weight (M.Wt): 751.87 g/mol

• Storage: Store at -20℃ (up to 3 years)

• Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro

• CAS No.: 129954-34-3

Neurochemical Mechanisms & Research Focus

Unlike conventional sedatives or non-selective central nervous system depressants, the selank peptide modulates neurotransmitter pathways without inducing sedation, physical dependence, or cognitive impairment. Key research pathways include:

• GABAergic System Modulation: Modulates $\text{GABA}_\text{A}$ receptor activity, increasing the amplitude and frequency of inhibitory postsynaptic currents to reduce stress-induced signaling.

• BDNF & Gene Expression: Elevates Brain-Derived Neurotrophic Factor (BDNF) expression in hippocampal tissue, facilitating synaptic plasticity, memory formation, and neuronal repair.

• Monoaminergic Regulation: Influences dopamine and serotonin turnover rates, maintaining neurotransmitter balance during acute environmental or physiological stress.

• Immunomodulatory Activity: Alters cytokine production (such as IL-6 and IL-1$\beta$), demonstrating a unique link between the central nervous system and immune responses.

Laboratory Formulations & Handling Standards

In preclinical settings, administrative methods vary depending on the target tissue and experimental framework. Formulations like a selank nasal spray are frequently evaluated in mucosal absorption assays due to direct olfactory-to-brain transport channels.

When establishing experimental parameters, calculating accurate selank dosage metrics in cellular and animal models is essential for avoiding target saturation and ensuring assay reproducibility. Standardizing selank peptide dosage protocols allows researchers to isolate specific cognitive markers while maintaining baseline metabolic stability across multi-well assays.

High-Purity Reagents by Receptor Chemicals

Receptor Chemicals provides analytical-grade research compounds engineered to meet rigorous laboratory standards. Every batch undergoes strict HPLC and mass spectrometry validation to deliver structural integrity, verified purity, and reproducible performance for non-clinical research applications.