Description

Advanced Receptor Research: KX-826 Pyrilutamide

KX-826 Pyrilutamide is a non-steroidal androgen receptor (AR) antagonist engineered for targeted topical research applications. Designed to evaluate receptor kinetics directly in dermal and follicular tissues, it functions by competitively binding to androgen receptors with high affinity. This targeted binding blocks endogenous androgens such as dihydrotestosterone (DHT) from triggering receptor-mediated signaling pathways locally without altering systemic hormone levels.

Technical & Product Specifications

• Size: 30ml | 5mg/ml | (30 x 5mg), 0.5%

• Molecular Weight (M.Wt): 482.43 g/mol

• IUPAC Name: 5-(1H-pyrazol-5-yl)-1-[2-[4-(trifluoromethoxy)phenoxy]ethyl]indole-2-carboxylic acid

• Solubility: Polyglycols, Aqua, Ethanol

• Purity: >99% Purity

• Storage: Store at -20℃ (up to 3 years)

• Estimated Half-Life: ~24 hours

• CAS No.: 1025658-44-9 (Referenced Variant) / 1272719-00-2

Mechanism of Action & Targeted Binding

In cellular and dermatological research models, local receptor inhibition remains a key strategy for investigating androgenic pathways. While systemic inhibitors target enzymatic pathways (such as 5-alpha reductase), non-steroidal receptor antagonists intervene downstream directly at the target site.

Researchers utilize this compound to study:

• Follicular Receptor Blockade: Evaluating competitive binding mechanisms in human dermal papilla cells to prevent androgen-induced cellular signaling.

• Sebaceous Gland Modulation: Observing the impact of receptor antagonism on androgen-driven lipid and sebum production dynamics.

• Localized Bioavailability: Testing specialized vehicle delivery formulations that maximize local dermal absorption while minimizing systemic circulation.

Laboratory Handling & Formulation Stability

Because topical bioavailability depends heavily on carrier chemistry, selecting the appropriate solvent system is critical during experimental setup. High-purity reference standards allow formulators to test penetration enhancers, ethanol-glycol vehicles, and lipid nanoparticles without baseline interference or degradation.

Proper storage at low temperatures (-20°C) preserves structural stability, ensuring that long-term comparative assays yield consistent, reproducible quantitative data.

Sourcing High-Purity Research Reagents

For academic institutions, biopharmaceutical laboratories, and cosmetic chemistry researchers, Receptor Chemicals supplies analytical-grade research compounds verified for structural identity and purity. Our stringent quality control measures ensure that every batch meets exact technical specifications to support your advanced research projects.