Description

Selective Androgen Receptor Research: LGD-4033

LGD-4033 (commonly known as Ligandrol) is a novel non-steroidal selective androgen receptor modulator (SARM) engineered for high-affinity binding to androgen receptors. By exhibiting high tissue selectivity for skeletal muscle and bone tissue over secondary androgenic organs, it serves as a critical analytical standard in biomedical research exploring muscle wasting conditions, osteopenia, and receptor signaling kinetics.

Technical & Product Specifications

• Sample Size: 10 mg / 30 ml (10 mg/ml)

• Purity: >98% (HPLC validated)

• Molecular Weight: 338.25 g/mol

• CAS No.: 1165910-22-4

• Solubility: Soluble in DMSO, Ethanol, and Polyethylene Glycol (PEG 400)

Pharmacological Mechanisms & Academic Research

Unlike non-selective anabolic androgenic steroids, LGD-4033 binds the androgen receptor with nanomolar affinity ($K_i \approx 1\text{ nM}$) without undergoing conversion to dihydrotestosterone (DHT) via $5\alpha$-reductase or aromatization into estrogenic metabolites. Academic institutions and bio-analytical laboratories utilize this chemical standard to evaluate key physiological responses:

• Anabolic vs. Androgenic Ratios: Assesses transcriptional activity in myoblasts while measuring reduced activity in prostate tissue models.

• Bone Mineral Density & Turnover: Evaluates osteoblast stimulation, anti-resorptive effects, and trabecular bone preservation in preclinical models.

• Receptor Affinity & Binding Kinetics: Acts as a reference control for evaluating ligand-binding domain (LBD) conformational changes and co-activator recruitment.

Laboratory Handling & Inventory Guidelines

When establishing protocol parameters for standardized assays, researchers evaluating an lgd-4033 dosage 30 mg total solution standard (such as 30 ml at 10 mg/ml concentrations) rely on strict purity metrics to ensure experimental reproducibility.

For academic labs and certified research organizations sourcing raw materials, finding the best website to buy lgd-4033 requires verifying third-party analytical documentation, HPLC purity assays, and mass spectrometry validation. Facilities seeking lgd-4033 for sale or comparing the standard lgd-4033 price across high-purity reagent vendors must ensure products are strictly designated for laboratory research rather than human consumption.

Quality Verification by Receptor Chemicals

Receptor Chemicals supplies high-purity reference materials synthesized to exacting specifications. Each batch undergoes rigorous testing to guarantee consistency, chemical stability, and complete structural verification across analytical, cellular, and bioenergetic research protocols.