Description

Advanced Circadian & Metabolic Research: SR9009

SR9009 (often referred to as Stenabolic) is a synthetic small-molecule REV-ERB agonist designed to selectively bind to and activate REV-ERB$\alpha$ and REV-ERB$\beta$ nuclear receptors. By modulating the constitutive repression of genes controlled by these core circadian clock regulators, it influences cellular energy expenditure, mitochondrial biogenesis, and metabolic homeostasis. High-purity reference standards of this compound are essential for laboratories studying physiological rhythmicity, lipid handling, and oxidative capacity.

Technical & Product Specifications

• Concentration & Volume: 30ml @ 10mg/ml | (30 x 10mg)

• Purity: >99% Purity

• Molecular Weight: 437.94 g/mol

• Chemical Name: ethyl-3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)pyrrolidine-1-carboxylate

• Solubility: Polyglycols

• Storage: Store at -20℃ (up to 3 years)

• Half Life: –

• CAS No.: 1379686-30-2

REV-ERB Agonism in Bioenergetic Studies

Activating REV-ERB receptors initiates metabolic shifts across diverse tissue models:

• Mitochondrial Biogenesis & Endurance: Upregulates mitochondrial content and oxidative gene networks in skeletal muscle cells, enhancing cellular oxygen consumption rates.

• Circadian & Lipid Regulation: Modulates hepatic clock genes involved in lipogenesis, lowering plasma triglycerides and glucose production in metabolic models.

• Inflammatory Dynamics: Demonstrates anti-inflammatory properties by suppressing key cytokine pathways in vascular and pulmonary tissue models.

Comparative Analysis: SR9011 vs SR9009

Researchers analyzing REV-ERB nuclear agonists frequently compare SR9011 vs SR9009 to determine structural and pharmacokinetic profiles. Both analogs target the same REV-ERB$\alpha$/$\beta$ receptors with similar nanomolar binding affinities. However, evaluation of sr9009 vs sr9011 in preclinical assays highlights minor variations in lipophilicity, half-life, and tissue distribution profiles, allowing investigators to select the precise agonist needed for specific cell-based assays.

Laboratory Sourcing & Handling Standards

Establishing accurate sr9009 dosage parameters in in vitro assays requires analytical-grade material free of structural isomers or residual synthesis contaminants. For analytical facilities evaluating options to buy SR9009 for non-clinical testing, sourcing certified compounds guarantees reproducible assay data and reliable batch-to-batch consistency.

High-Purity Reagents by Receptor Chemicals

Receptor Chemicals delivers analytical-grade compounds engineered for strict laboratory standards. Every lot undergoes rigorous testing to verify purity and molecular structure, supporting advanced bioenergetic and metabolic research worldwide.