Description
Tissue Repair and Actin Dynamics: TB500 (TB4 – Thymosin Beta-4)
It a synthetic peptide containing the full 43-amino-acid chain sequence found naturally throughout mammalian tissues. Functioning primarily as an actin-sequestering protein, it regulates cell motility, cytoskeletal structure, and tissue remodeling. By binding to G-actin monomers, it maintains a pool of unpolymerized actin necessary for cell migration, cellular repair, and vascular growth in bioenergetic and physiological studies.
Technical & Product Specifications
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Size: 5mg / 10mg
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Purity: >99% Purity
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Sequence: Thymosin Beta-4 (Full 43-amino chain)
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Molecular Weight: 4,921 g/mol
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Storage: Store at -20℃ (up to 3 years)
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CAS No.: 77591-33-4
Mechanisms of Action in Laboratory Models
In preclinical cellular models, thymosin beta-4 demonstrates several pathways related to tissue repair and cell survival:
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Actin Dynamics & Cell Migration: Binds to actin filaments to facilitate rapid cell movement to sites of injury, supporting endothelial cell migration and wound healing assays.
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Angiogenesis: Promotes the formation of new blood vessels by upregulating endothelial cell differentiation and capillary tube formation.
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Anti-Inflammatory Modulation: Downregulates pro-inflammatory cytokines and nuclear factor-kappa B (NF-$\kappa$B) signaling pathways to decrease oxidative stress and localized tissue damage.
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Extracellular Matrix Remodeling: Supports collagen deposition and cellular recruitment needed for tendon, ligament, and cardiac tissue repair studies.
Experimental Handling & Formulations
Researchers evaluating tb-500 thymosin beta-4 utilize lyophilized preparations to ensure long-term molecular stability. Standard research protocols involve reconstituting thymosin beta-4 5mg or tb-500 thymosin beta-4 10mg vials using aqueous solvents like sterile water for multi-well cellular assays or targeted animal model studies. Maintaining high chromatographic purity (>99%) is critical to prevent degradation products from altering experimental endpoints in cell motility and receptor binding studies.
Sourcing High-Purity Peptides
Receptor Chemicals provides analytical-grade compounds engineered for strict scientific consistency. Each batch of TB500 (TB4 – Thymosin Beta-4) undergoes quality control testing to confirm structural sequence integrity, purity, and freedom from manufacturing contaminants.
