Description

Advanced Nootropic Research: N-Acetyl Semax Amidate

N-Acetyl Semax Amidate is an extensively modified synthetic heptapeptide analog derived from adrenocorticotropic hormone (ACTH 4-10). Renowned in neurobiology and cognitive research, this double-modified peptide undergoes both N-terminal acetylation and C-terminal amidation. These precise structural alterations significantly enhance enzymatic resistance, enabling prolonged metabolic stability and crossing the blood-brain barrier with far greater efficiency than the parent peptide.

Technical & Product Specifications

• Quantity Options: Available in standard vials and n-acetyl semax amidate 30mg configurations.

• Purity: >99% Purity (HPLC Verified)

• CAS No.: 2920938-90-3

• Molecular Weight: 854.98 g/mol

• Sequence: Ac-Met-Glu-His-Phe-Pro-Gly-Pro

• Storage: Store lyophilized powder at 20°C.

Mechanistic Action in Neurobiology

When laboratories evaluate the n-acetyl semax amidate peptide in experimental models, research focuses primarily on its neurotrophic and neuroprotective capabilities:

• BDNF & NGF Upregulation: Stimulates the expression of Brain-Derived Neurotrophic Factor and Nerve Growth Factor, promoting synaptic plasticity, neurogenesis, and neuronal survival.

• Neurotransmitter Modulation: Regulates dopaminergic and serotonergic turnover, encouraging heightened focus, mental stamina, and stress resilience under hypoxia or ischemic conditions.

• Melanocortin Receptor Signaling: Interacts with central melanocortin receptors without triggering peripheral adrenocorticotropic activity.

Laboratory Formulation & Administration Research

Determining the accurate n-acetyl semax amidate dosage protocol depends on the specific in-vitro or animal research model being deployed. Because of its enhanced metabolic resistance, smaller molar concentrations are required to achieve target receptor saturation compared to unmodified Semax. In intranasal experimental setups, an n-acetyl semax amidate spray vehicle offers immediate systemic absorption, avoiding hepatic first-pass metabolism and providing a rapid, steady-state bio-delivery profile.

Sourcing High-Purity Research Peptides

For academic institutions, neurobiological research facilities, and analytical laboratories requiring uncompromising quality, Receptor Chemicals supplies analytical-grade research compounds. Every lot is strictly tested to guarantee high purity, structural integrity, and batch-to-batch consistency for your most demanding clinical assays.