Description

Advanced Bioenergetic Research: BAM15

BAM15 is a small-molecule mitochondrial protonophore uncoupler that selectively depolarizes the inner mitochondrial membrane without altering the plasma membrane potential. By dissipating the electrochemical proton gradient across the inner membrane, it uncouples nutrient oxidation from oxidative phosphorylation (ATP synthesis). This mechanism stimulates cellular respiration, increases oxygen consumption, and elevates metabolic flux, making it a critical reference standard in bioenergetic and metabolic research.

Technical & Product Specifications

• Sample Size: 30ML 25MG/ML

• Purity: >99% Purity

• Molecular Weight: 340.29 g/mol

• CAS No.: 210302-17-3

Selective Uncoupling & Metabolic Research

Unlike classical uncoupling agents such as FCCP or DNP, which depolarize both mitochondrial and plasma membranes, this synthetic compound exhibits a distinct therapeutic window by targeting only the inner mitochondrial membrane. Researchers widely evaluate its role across several key biochemical pathways:

• Mitochondrial Respiration & ROS Reduction: Dissipates excess proton motive force, reducing superoxide and reactive oxygen species (ROS) generation at Complexes I and III without causing cytotoxic plasma membrane depolarization.

• Lipid Metabolism & Energy Expenditure: Activates AMP-activated protein kinase (AMPK) and PGC-1$\alpha$, driving substrate oxidation and mitochondrial biogenesis in cellular models.

• Preclinical Disease Models: Provides valuable analytical insights into insulin sensitivity, hepatic lipid accumulation, inflammatory responses, and ischemic-reperfusion organ protection.

Laboratory Sourcing & Handling Standards

While categorized alongside metabolic research agents, queries regarding a bam15 peptide reflect common cataloging misunderstandings, as it is a small-molecule pyrazine derivative rather than an amino acid chain. Determining the precise bam15 dosage and concentration parameters in in vitro assays requires analytical-grade purity to maintain experimental validity.

For facilities evaluating bam15 where to buy options or searching for high-purity bam15 for sale for non-clinical analytical testing, sourcing from reputable vendors ensures batch consistency, verified molecular integrity, and complete freedom from residual impurities.

High-Purity Reagents by Receptor Chemicals

Receptor Chemicals provides analytical-grade research compounds engineered to satisfy rigorous scientific standards. Every batch undergoes strict quality control validation to deliver reproducible results across bioenergetic assays, cell culture experiments, and metabolic studies.