Description
High-Purity Research Peptides: TB500
TB500 is a synthetic research peptide derived from the active functional domain of Thymosin Beta-4, a naturally occurring 43-amino-acid actin-sequestering protein. By isolating the essential active sequence (residues 17–23, Ac-LKKTETQ-OH), researchers can investigate targeted cellular signaling without the structural complexity of the parent protein. In laboratory assays, this short-chain peptide serves as a primary standard for studying actin polymerization, cell migration, and tissue repair kinetics.
Technical & Product Specifications
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Size: 5mg | 10mg
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Purity: >99% Purity
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Molecular Weight: 889.01 g/mol
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Storage: Store at -20℃ (up to 3 years)
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Half-Life: ~2.5 days (biological persistence in tissue models)
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CAS No.: 885340-08-9
Mechanisms of Action in Cellular Research
The primary biological interest in the tb500 peptide lies in its low molecular weight (~889 Da) and high mobility within extracellular matrices. Key mechanisms studied in cellular models include:
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Actin Dynamics: Regulates unattached G-actin monomers, facilitating cellular remodeling, motility, and cytoskeletal maintenance during cellular migration.
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Angiogenesis: Promotes microvascular endothelial cell differentiation and capillary tube formation in vitro.
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Inflammatory Modulation: Downregulates specific pro-inflammatory cytokines while supporting matrix metalloproteinase production to encourage cell adhesion.
Research Protocols and Synergistic Stacks
In experimental assays, researchers often examine dual-peptide configurations to evaluate complementary regenerative pathways. Combining bpc157 tb500 offers an analytical model for investigating dual-action tissue repair—where BPC-157 acts on local growth factor pathways while $\text{T}\beta4$ fragments modulate systemic cell migration.
Establishing precise tb500 dose parameters and determining proper bpc157 tb500 dosage ratios in cell culture experiments requires high-purity, analytical-grade compounds to avoid baseline variance or cytotoxic interference.
Analytical Grade Sourcing
For academic laboratories, biopharmaceutical research units, and chemical testing facilities, Receptor Chemicals provides high-purity research materials manufactured under stringent laboratory standards. Each lot undergoes comprehensive mass spectrometry and HPLC analysis to guarantee structural identity, purity, and batch consistency for non-clinical research applications.
