Description
Selective Estrogen Receptor Modulation: Enclomiphene
Enclomiphene is the trans-isomer (E-isomer) of clomiphene, functioning as a potent, non-steroidal selective estrogen receptor modulator (SERM) and estrogen receptor antagonist. By competitively blocking estrogen receptors in the hypothalamus and pituitary gland, it interrupts negative feedback loops, prompting an endogenous surge in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion.
Technical & Product Specifications
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Purity: >98% (HPLC Verified)
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CAS Number: 7599-79-3 (Citrate salt) / 15690-57-0 (Free base)
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Molecular Weight: 598.08 g/mol (Citrate)
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Solubility: Soluble in DMSO; insoluble in water
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Storage: Store at -20°C, protected from light and moisture
Pharmacological Mechanism & Research Applications
Unlike classical clomiphene mixtures—which combine both trans- and cis-isomers (the latter exhibiting estrogen agonist activity)—isomerically pure enclomiphene citrate provides targeted anti-estrogenic action. Academic and biomedical research labs utilize this compound to analyze hypothalamus-pituitary-gonadal (HPG) axis dynamics:
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Gonadotropin Signaling: Evaluates upstream pulse stimulation of pituitary gonadotropins and downstream testicle Leydig cell response models.
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Endocrine Profiling: Serves as a reference standard in comparative assays investigating enclomiphene for men experiencing secondary hypogonadotropic hypogonadism pathways.
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Receptor Antagonism Mapping: Measures binding affinity parameters relative to nuclear estrogen receptors without unwanted mixed agonist side effects.
Analytical Sourcing & Laboratory Standards
When investigating options for enclomiphene buy orders or evaluating analytical grade compounds, research institutions emphasize verified high purity and batch consistency. Misconceptions sometimes lead inquiries toward a structural enclomiphene peptide designation; however, it remains a small-molecule triphenylethylene derivative rather than an amino acid sequence.
Securing reliable batches for in vitro analytical work requires trusted synthesis pathways to ensure exact molecular weight and complete isomeric isolation.
Quality Control by Receptor Chemicals
Receptor Chemicals delivers premium-grade research compounds manufactured under stringent quality protocols. Each batch undergoes high-performance liquid chromatography and mass spectrometry validation to guarantee reproducibility across academic and institutional facilities.
