Description

Advanced Metabolic Research Reagents: AICAR

AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide), also known as acadesine monophosphate or ZMP, is an essential nucleotide analog widely utilized in cellular and metabolic research. Functioning primarily as a direct intracellular activator of 5′-AMP-activated protein kinase (AMPK), it plays a crucial role in investigating cellular energy homeostasis, glucose uptake, and lipid oxidation pathways. Sourcing high-purity chemical reagents ensures that analytical laboratories can conduct precise assay protocols without interferences from synthesis byproducts.

Technical & Product Specifications

• Size: 50mg

• Purity: >99% (HPLC)

• Molecular Weight: 338.211 g/mol

• Form: Lyophilized Powder (Requires reconstitution; sterile water for reconstitution supplied separately)

• CAS No.: 3031-94-5

AMPK Activation and Cellular Mechanisms

In metabolic studies, researchers evaluate AMPK activation to observe how cells respond to shifts in energy availability. As a active monophosphate derivative, the compound directly mimics intracellular AMP levels to stimulate kinase pathways. Investigating the aicar peptide signaling axis allows researchers to examine:

• Mitochondrial Biogenesis: Observing the upregulation of PGC-1α and cellular respiration rates.

• Glucose Transport: Analyzing insulin-independent GLUT4 translocation and intracellular glucose clearance.

• Fatty Acid Oxidation: Tracking carnitine palmitoyltransferase-1 (CPT-1) activation and lipid metabolism pathways.

Assay Optimization and Sourcing Requirements

Determining the correct aicar peptide dosage parameters within experimental models is essential for maintaining cell viability and obtaining reproducible signal-to-noise ratios during high-throughput screening. Standardized laboratory handling protocols dictate precise buffer reconstitution and temperature management to preserve compound stability over long-term storage periods.

For research institutions planning to buy aicar for analytical trials, finding a verified supply chain prevents batch variations that compromise quantitative data. When evaluating options for aicar for sale, biopharmaceutical facilities prioritize verified purity profiles backed by rigorous HPLC analysis and mass spectrometry verification.

Premium Research Chemicals

At Receptor Chemicals, we specialize in providing analytical-grade compounds engineered to satisfy demanding research standards. Our commitment to strict quality control ensures high structural integrity and batch consistency across every laboratory solution we deliver.