Description

Advanced Enzyme Modulation: 5-Amino-1MQ

5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule membrane-permeable enzyme inhibitor gaining significant focus in metabolic, cellular signaling, and energetic research. It functions primarily as a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme heavily expressed in adipose tissue and skeletal muscle that regulates cellular energy metabolism. SourcinDiscover high-purity 5-Amino-1MQ (CAS No. 42464-96-0) at Receptor Chemicals, featuring ≥98% pure NNMT enzyme inhibitors engineered for cellular energy, NAD+ pathway, and metabolic researchg analytical-grade reference compounds is essential for laboratories conducting baseline metabolic screening and enzyme kinetics studies.

Technical & Product Specifications

• Sample Size: 50ml / Lyophilized Vials

• Purity: ≥98% Purity (HPLC)

• CAS No.: 42464-96-0

• Molecular Weight: 159.21 g/mol (free base) / 286.11 g/mol (iodide salt)

• Storage: Store at -20°C

Enzymatic Mechanism and Research Scope

In cellular biology, NNMT transfers methyl groups from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide (MNA). By inhibiting NNMT activity, 5-Amino-1MQ allows researchers to study several core pathways:

• NAD+ Salvage Pathway: Preventing NNMT consumption of nicotinamide preserves substrates necessary for NAD+ synthesis, enhancing cellular energy homeostasis and mitochondrial efficiency.

• S-Adenosylmethionine (SAM) Preservation: Reducing methyl group depletion helps maintain epigenetic methyl donor pools required for gene expression regulation and histone methylation.

• Adipocyte & Muscle Physiology: Research models demonstrate that blocking NNMT reduces intracellular fat accumulation without impairing glucose transport, making it a critical reference standard in metabolic regulation studies.

Laboratory Formulations & Dosing Protocols

When evaluating NNMT inhibition in laboratory environments, investigators utilize specialized assays to measure kinetic parameters. While researchers often assess oral delivery models using 5-amino-1mq capsules, in vitro and specialized animal models frequently evaluate targeted administration routes to observe localized tissue response.

Evaluating a 5-amino-1mq dosage requires careful calibration based on assay design and subject mass. In preclinical rodent studies, researchers exploring systemic absorption often benchmark a 5-amino-1mq dosage subcutaneous administration protocol alongside oral pathways to compare bio-availability, peak plasma concentration, and tissue distribution profiles. Often grouped alongside metabolic regulators, this synthetic compound acts as a distinct small molecule rather than a traditional 5-amino-1mq peptide structure.

High-Purity Reagents for Advanced Research

For academic institutions, biopharmaceutical laboratories, and analytical researchers, Receptor Chemicals provides high-grade compounds engineered to strict quality control parameters. Our reference standards undergo thorough testing to ensure structural validation, high purity, and reproducible performance in demanding laboratory settings.