Description

Novel Amylin Agonists: Cagri

Cagri is a prominent focus in metabolic research, representing a long-acting synthetic analog of human amylin (islet amyloid polypeptide). As a non-selective agonist of both amylin receptors (AMYR) and calcitonin receptors (CTR), it provides researchers with a powerful tool for investigating neuro-endocrine control, appetite regulation, and satiety pathways. Utilizing high-purity reference materials is crucial for laboratories studying receptor binding kinetics and downstream signal transduction.

Technical & Product Specifications

• Size: 5mg

• Purity: >99% Purity

• Molecular Weight: ~4,409 g/mol

• Storage: Store at -20℃ (up to 3 years)

• CAS No.: 1415456-99-3

Amylin Mimetic Mechanisms in Experimental Biology

Unlike standard single-target satiety peptides, cagrilintide features structural modifications—including fatty acid lipidation—that significantly extend its biological half-life by enabling albumin binding. In cellular and animal models, it mimics the endogenous action of amylin:

• Satiety Signaling: Acts directly on homeostatic and hedonic brain regions to signal fullness and regulate food intake.

• Gastric Emptying Control: Delays postprandial gastric transit times to moderate glucose influx.

• Synergistic Co-Agonism: Evaluated alongside GLP-1 receptor agonists to explore additive effects on energy balance and fat oxidation.

This distinct mechanism allows researchers to examine how amylin pathway modulation operates independently of or in conjunction with traditional incretin receptors.

Assay Optimization and Sourcing

When establishing reproducible experimental protocols, utilizing properly lyophilized compounds like cagrilintide 5mg ensures precise mass measurements, high stability, and seamless reconstitution in aqueous buffers. Maintaining analytical-grade purity is essential to prevent confounding variable responses in baseline metabolic assays.

Sourcing High-Purity Research Reagents

For academic institutions, biotechnology labs, and analytical research teams, Receptor Chemicals offers top-tier peptide compounds engineered to meet rigorous scientific criteria. Our products undergo comprehensive quality verification, guaranteeing structural integrity and batch-to-batch consistency for demanding experimental applications.