Description

Premium Growth Hormone Releasing Analogs: CJC-1295 no DAC

CJC-1295 no DAC (also widely classified in research literature as Modified GRF 1-29) is a synthetic 29-amino acid tetrasubstituted peptide analogue of native growth hormone-releasing hormone (GHRH). Engineered to bind directly to GHRH receptors on pituitary somatotroph cells, it stimulates the endogenous synthesis and pulsatile release of growth hormone (GH). Sourcing high-purity, analytical-grade reference materials is essential for laboratories investigating pituitary signaling pathways and peptide dynamics.

Technical & Product Specifications

• Size: 5mg

• Purity: >99% Purity

• Molecular Weight: ~3,367.9 g/mol

• Storage: Store at -20℃ (Desiccated)

• CAS No.: 863288-34-0

Pharmacokinetics & Receptor Interaction

Understanding the specific cjc-1295 no dac half-life is critical for establishing effective laboratory dosing schedules. Unlike long-acting variants that incorporate the Drug Affinity Complex (DAC) to extend half-life via albumin conjugation, the non-DAC variant lacks this chemical attachment. Consequently, it exhibits a rapid circulating half-life of approximately 30 minutes. This abbreviated clearance window allows researchers to closely mimic natural, physiological GH pulses without inducing continuous baseline elevation.

Synergistic Research & Combination Assays

In metabolic and endocrinological models, researchers frequently evaluate the combined mechanism of cjc-1295 no dac + ipamorelin. When co-administered in research settings, these two distinct secretagogues operate through complementary pathways:

• GHRH Pathway Activation: Modified GRF 1-29 stimulates adenylate cyclase via GHRH receptors.

• Ghrelin Receptor Agonism: Ipamorelin selectively targets ghrelin/GHS-R1a receptors.

This dual-action approach triggers a synergistic amplification of growth hormone secretion far exceeding the baseline response of either compound alone, while minimizing unwanted cortisol or prolactin spikes.

Procurement & Laboratory Standards

For academic facilities and qualified institutions seeking to buy cjc-1295 no dac, maintaining stringent quality control parameters prevents experimental baseline drift. Authentic cjc-1295 no dac for sale must be validated through High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS) to verify precise sequence alignment and batch consistency.

At Receptor Chemicals, our inventory undergoes rigorous analytical testing to guarantee consistent, high-purity reference standards for demanding research protocols.