Description
Advanced Selective Androgen Receptor Modulator: YK11
YK11 is a synthetic, steroidal compound categorized as a gene-selective partial agonist of the androgen receptor (AR). Known for its unique dual mechanism of action, it binds to androgen receptors while simultaneously stimulating the expression of follistatin—an autocrine glycoprotein that inhibits myostatin activity in muscular tissue. This dual capability makes it an invaluable reference standard in biochemical, cellular, and musculoskeletal research.
Technical & Product Specifications
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Liquid Configuration: 30ml @ 10mg/ml (300mg total per vial)
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Purity: >99% Purity
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Molecular Weight (M.Wt): 430.53 g/mol
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Vehicle / Solubility: Polyglycols (PEG)
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Storage: Store at -20℃ (up to 3 years)
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Half Life: Under active study (pharmacokinetic baseline evaluation)
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CAS No.: 431579-34-9
Mechanism of Action & Research Focus
While widely grouped into the yk11 sarm category, YK11 possesses a distinct steroidal backbone derived from 5-$\alpha$-dihydrotestosterone (DHT). Researchers actively investigate its properties across key physiological domains:
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Myostatin Inhibition via Follistatin: Induces significant expression of follistatin mRNA in myoblast models, suppressing myostatin pathways that naturally limit muscle cell differentiation and proliferation.
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Androgen Receptor Gene Transactivation: Acts as a partial AR agonist without inducing typical full transactivation N/C interactions, permitting the study of selective downstream target genes.
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Osteogenic Marker Upregulation: Elevates alkaline phosphatase (ALP) activity and osteocalcin gene expression in osteoblast cell lines, offering insight into bone mineralization processes.
Laboratory Handling & Pharmacokinetic Parameters
Determining precise yk11 dosage ranges in cell culture models is necessary to evaluate its comparative potency against classical androgen receptor agonists like DHT. In preclinical pharmacokinetics, assessing parameters such as the yk11 half life and metabolic clearance rates helps establish accurate dosing intervals for experimental assays. Furthermore, comparing raw powder preparations against injectable yk11 vehicle preparations or polyglycol-solubilized liquid solutions allows researchers to analyze differences in bioavailability and solution stability. High-purity compounds are mandatory to ensure consistent experimental reproducibility and eliminate potential cross-reactivity in vitro.
Premium Research Reagents by Receptor Chemicals
Receptor Chemicals provides analytical-grade compounds engineered for rigorous scientific investigation. Each batch of YK11 undergoes stringent quality control validation to guarantee structural integrity, high purity, and complete absence of residual synthesis impurities for advanced research applications.
