Description

Innate Immunity & Cellular Defense: LL-37

LL-37 is an amphipathic, alpha-helical antimicrobial peptide belonging to the cathelicidin family. Naturally generated as the active C-terminal fragment of human cationic antimicrobial protein (hCAP18), this synthetic peptide serves as a pivotal reference compound in immunological, tissue repair, and host-defense research. Its positively charged structural architecture enables direct binding to negatively charged bacterial membranes, making it an essential subject for observing membrane disruption dynamics and inflammatory signaling pathways.

Technical & Product Specifications

• Sample Size: 5mg

• Purity: >99% (HPLC Verified)

• Molecular Weight (M.Wt): 4,493.3 g/mol

• Storage: Store at -20℃ (up to 3 years)

• CAS No.: 154947-66-7

Key Research Mechanisms & Pathways

Investigating the functional characteristics of the ll-37 peptide provides valuable insights into both innate cellular defenses and adaptive immune responses:

• Bacterial Membrane Disruption: The amphipathic alpha-helical structure binds preferentially to anionic bacterial outer membranes, inducing pore formation and structural lysis.

• Chemotaxis & Receptor Activation: Functions as a chemoattractant for neutrophils, monocytes, and T-cells by interacting with Formyl Peptide Receptor-Like 1 (FPRL1).

• Wound Healing & Angiogenesis: Promotes endothelial cell proliferation, migration, and re-epithelialization in vascular and tissue repair models.

• Immunomodulation: Regulates pro-inflammatory and anti-inflammatory cytokine release depending on extracellular signaling microenvironments.

Sourcing High-Purity Research Compounds

For laboratories seeking to buy ll-37 peptide stocks, analytical consistency and verified sequence integrity are critical for generating reproducible data. Research applications requiring ll-37 peptide for sale demand high purity to eliminate background noise in cell culture assays and binding affinity studies. Evaluating structural stability across reconstitution buffers ensures long-term viability during multi-well testing procedures.

Facilities preparing to buy ll-37 for analytical protocols can rely on Receptor Chemicals for high-grade synthetic peptides tested for molecular weight accuracy and sequence fidelity. Our supply chain guarantees reliable, batch-verified research compounds tailored for strict experimental requirements.